Effects of extracellular Ca++, K+, and Na+ on cone and retinal pigment epithelium retinomotor movements in isolated teleost retinas.

We have examined the effects of changes in extracellular ionic composition on cone and retinal pigment epithelium (RPE) retinomotor movements in cultured isolated teleost retinas. In vivo, the myoid portion of teleost cones contracts in the light and elongates in the dark; RPE pigment disperses in the light and aggregates in the dark. In vitro, cones of dark-adapted (DA) retinas cultured in constant darkness contracted spontaneously to their light-adapted (LA) positions if the culture medium contained greater than or equal to 10(-3)M Cao++. DA cones retained their long DA positions in a medium containing less than or equal to 10(-6)M Cao++. Low [Ca++]o (10(-5)-10(-7)M) also permitted darkness to induce cone elongation and RPE pigment aggregation. Light produced cone contraction even in the absence of Cao++, but the extent of contraction was reduced if [Ca++]o was less than 10(-3) M. Thus, full contraction appeared to require the presence of external Ca++. High [K+]o (greater than or equal to 27 mM) inhibited both light-induced and light-independent Ca++-induced cone contraction. However, low [Na+]o (3.5 mM) in the presence of less than or equal to 10(-6)M Cao++ did not mimic light onset by inducing cone contraction in the dark. High [K+]o also promoted dark-adaptive cone and RPE movements in LA retinas cultured in the light. All results obtained in high [K+]o were similar to those observed when DA or LA retinas were exposed to treatments that elevate cytoplasmic cyclic 3,5-adenosine monophosphate (cAMP) content

Construction of a Penrose Diagram for a Spatially Coherent Evaporating Black Hole

A Penrose diagram is constructed for an example black hole that evaporates at a steady rate as measured by a distant observer, until the mass vanishes, yielding a final state Minkowski space-time. Coordinate dependencies of significant features, such as the horizon and coordinate anomalies, are clearly demonstrated on the diagram. The large-scale causal structure of the space-time is briefly discussed.Comment: 12 pages, 3 figure

Reflections in a Polished Tube

When one of us (E.B.M.) dislodged a metal tube from an electric door chime recently, she inadvertently introduced her father to an attractive and instructive optical phenomenon. Looking down the highly polished inner surface of the cylinder we could see a spot surrounded by a series of bright concentric rings. The pattern looked much like the display of fringes produced by a Fabry-Perot or Michelson interferometer, except that the rings were more evenly spaced instead of crowding together strongly near the edge of the field of view. [excerpt

The Dynamic Impact of Periodic Review on Women’s Rights

Human rights treaty bodies have been frequently criticized as useless and the regime’s self-reporting procedure widely viewed as a whitewash. Yet very little research explores what, if any, influence this periodic review process has on governments’ implementation of and compliance with treaty obligations. We argue oversight committees may play an important role in improving rights on the ground by providing information for international and primarily domestic audiences. This paper examines the cumulative effects on women’s rights of self-reporting and oversight review, using original data on the history of state reporting to and review by the Committee on the Elimination of Discrimination against Women (CmEDAW). Using a dynamic approach to study the effects of the periodic review process, we find that self-reporting has a significant positive effect on women’s rights. We explore three clusters of evidence for the domestic mobilization mechanism: information provision through domestic civil society organizations; publicity and critique through the domestic media; and parliamentary attention, debate, and implementation of recommendations. This is the first study to present positive evidence on the effects of self-reporting on rights and to describe the mechanisms that link Geneva bodies with local politics. Our findings challenge the received wisdom that the process of reporting to these treaty bodies is basically useless